Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10596687 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
We demonstrate the synthesis and selective binding of two novel furan based tricyclic homo-oligopeptides to G-quadruplex and using Real Time PCR show its repressive effect on c-MYC transcription. CD spectroscopy and FRET melting studies show that these ligands can induce G-quadruplex structures in the G rich 22 mer c-MYC DNA sequence and further stabilize the structure. Using real time polymerase chain reaction we observed that up to 70% downregulation of c-MYC transcripts upon ligand treatment in HeLa cells.
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Authors
Tani Agarwal, Saumya Roy, Tushar Kanti Chakraborty, Souvik Maiti,