| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10596688 | Bioorganic & Medicinal Chemistry Letters | 2010 | 5 Pages |
Abstract
6-Phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives were identified as selective human cathepsin S inhibitors with a stable thiol trapping nitrile war-head. A novel TFA based Boc deprotection method is also described. This new method uses acetonitrile as a co-solvent to remove t-butyl cation related side reactions by an in situ 'Ritter' reaction.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
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Authors
Jiaqiang Cai, Mark Baugh, Darcey Black, Clive Long, D. Jonathan Bennett, Maureen Dempster, Xavier Fradera, Jonathan Gillespie, Fiona Andrews, Sylviane Boucharens, John Bruin, Kenneth S. Cameron, Iain Cumming, William Hamilton, Philip S. Jones,