| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10596724 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
The novel 2,4-diaminoquinazolines 3-5 were easily prepared based on the reaction of polyhaloisophthalonitriles with guanidine carbonate. The anticancer and anti-HIV activities of 3-5 were evaluated in vitro. Compound 5a was the most potent derivative against the five tumor cell lines with an IC50 value lower than 2.5 μg/mL, and 3c showed the most potent anti-HIV-1 activity with EC50 values of 0.6 and 1.6 μg/mL, and TI values of >59.6 and 66.6, respectively.
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Authors
Sheng-Jiao Yan, Han Zheng, Chao Huang, Yu-Yun Yan, Jun Lin,