| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10596732 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
2-Phenyl-9H-purine-6-carbonitrile derivatives were designed as selective human cathepsin S inhibitors through P2 optimization and transition state stabilization by an intramolecular H-bond.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jiaqiang Cai, D. Jonathan Bennett, Zoran Rankovic, Maureen Dempster, Xavier Fradera, Jonathan Gillespie, Iain Cumming, William Finlay, Mark Baugh, Sylviane Boucharens, John Bruin, Kenneth S. Cameron, William Hamilton, Jennifer Kerr, Emma Kinghorn,