| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10596751 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
Design, syntheses and structure-activity relationships of piperazine privileged structures containing MC4R agonist compounds 6 were described. The most potent derivatives were low nM MC4R selective full agonists. Several compounds from the series had modest pharmacokinetic properties.
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Authors
Qingmei Hong, Raman K. Bakshi, James Dellureficio, Shuwen He, Zhixiong Ye, Peter H. Dobbelaar, Iyassu K. Sebhat, Liangqin Guo, Jian Liu, Tianying Jian, Rui Tang, Rubana N. Kalyani, Tanya MacNeil, Aurawan Vongs, Charles I. Rosenblum, David H. Weinberg,