| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10596755 | Bioorganic & Medicinal Chemistry Letters | 2010 | 5 Pages |
Abstract
A novel series of 4-[3,5-dioxo-11-oxa-4,9-diazatricyclo[5.3.1.02,6]undec-4-yl]-2-trifluoromethyl-benzonitriles has been synthesized. The ability of these compounds to act as antagonists of the androgen receptor was investigated and several were found to have potent activity in vitro and in vivo.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
![Design and synthesis of 4-[3,5-dioxo-11-oxa-4,9-diazatricyclo[5.3.1.02,6]undec-4-yl]-2-trifluoromethyl-benzonitriles as androgen receptor antagonists](/preview/png/10596755.png "First Page Preview: Design and synthesis of 4-[3,5-dioxo-11-oxa-4,9-diazatricyclo[5.3.1.02,6]undec-4-yl]-2-trifluoromethyl-benzonitriles as androgen receptor antagonists")
Authors
Hai-Yun Xiao, Aaron Balog, Ricardo M. Attar, David Fairfax, Linda B. Fleming, Christian L. Holst, Gregory S. Martin, Lana M. Rossiter, Jing Chen, Mary-Ellen Cvjic, Janet Dell-John, Jieping Geng, Marco M. Gottardis, Wen-Ching Han, Andrew Nation,