| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10596763 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
The N3 nitrogen of the pyrimidine-2-carbonitrile based cathepsin cysteine protease inhibitors is critically important. An 'in situ double activation' mechanism was postulated to explain these results. A novel expanded S2 binding pocket for human cathepsin S enzyme was also identified.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jiaqiang Cai, Xavier Fradera, Mario van Zeeland, Maureen Dempster, Kenneth S. Cameron, D. Jonathan Bennett, John Robinson, Lucy Popplestone, Mark Baugh, Paul Westwood, John Bruin, William Hamilton, Emma Kinghorn, Clive Long, Joost C.M. Uitdehaag,