Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10596780 | Bioorganic & Medicinal Chemistry Letters | 2010 | 5 Pages |
Abstract
Working off the previously discovered sphingosine kinase-1 (SK1) inhibitor 4, structural optimization resulted in identification of a new series of analogs exemplified by compound 51 which have improved aqueous solubility and ADME properties while maintain or enhance enzyme potency. The lead 51 has also demonstrated modest oral bioavailability in a rat PK study.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yibin Xiang, Bradford Hirth, John L. Jr., Junkai Liao, Kevin D. Noson, Christopher Yee, Gary Asmussen, Maria Fitzgerald, Christine Klaus, Michael Booker,