| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10596792 | Bioorganic & Medicinal Chemistry Letters | 2010 | 5 Pages |
Abstract
A rational design approach around a new pyrrole core with modulation of the topological polar surface area allowed the identification of the potent, selective and peripherally-restricted CB1 antagonist 11 [XÂ =Â -(CH2)3NHSO2Me; RÂ =Â (4,4-difluoropiperidyl)] with a IC50 (hCB1)Â =Â 1.4Â nM.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Laurent Hortala, Murielle Rinaldi-Carmona, Christian Congy, Laurent Boulu, Freddy Sadoun, Gérard Fabre, Olivier Finance, Francis Barth,