| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10596795 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
Efficient regioselective syntheses of conjugates of folic acid and cytotoxic agents derived from natural epothilones are described. These folate receptor (FR) targeting compounds are water soluble and incorporate a hydrophilic peptide-based spacer unit and a reducible self-immolative disulfide-based linker system between the FR-targeting ligand and the parent drug.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Iontcho R. Vlahov, Gregory D. Vite, Paul J. Kleindl, Yu Wang, Hari Krishna R. Santhapuram, Fei You, Stephen J. Howard, Soong-Hoon Kim, Francis F.Y. Lee, Christopher P. Leamon,