| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10596803 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
Dermal application of the potent FLAP inhibitor, 6 (AM643) using a prototypical vehicle in a murine ear arachidonic acid model showed significant reduction in the concentrations of leukotrienes in mouse skin with concomitant reduction in ear swelling.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
![5-Lipoxygenase-activating protein inhibitors. Part 3: 3-{3-tert-Butylsulfanyl-1-[4-(5-methoxy-pyrimidin-2-yl)-benzyl]-5-(5-methyl-pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM643)-A potent FLAP inhibitor suitable for topical administ](/preview/png/10596803.png "First Page Preview: 5-Lipoxygenase-activating protein inhibitors. Part 3: 3-{3-tert-Butylsulfanyl-1-[4-(5-methoxy-pyrimidin-2-yl)-benzyl]-5-(5-methyl-pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM643)-A potent FLAP inhibitor suitable for topical administ")
Authors
Nicholas Stock, Christopher Baccei, Gretchen Bain, Charles Chapman, Lucia Correa, Janice Darlington, Christopher King, Catherine Lee, Daniel S. Lorrain, Pat Prodanovich, Angelina Santini, Kevin Schaab, Jilly F. Evans, John H. Hutchinson, Peppi Prasit,