| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10596807 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
Pyridopyridazine antagonists of the hedgehog signaling pathway are described. Designed to optimize our previously described phthalazine smoothened antagonists, a representative compound, 27, eliminates a PXR liability while retaining potency and in vitro metabolic stability. Moreover, the compound has improved efficacy in a hedgehog/smoothened signaling mouse pharmacodynamic model.
Keywords
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jacob A. Kaizerman, Wade Aaron, Songzhu An, Richard Austin, Matt Brown, Angela Chong, Tom Huang, Randall Hungate, Ben Jiang, Michael G. Johnson, Gary Lee, Brian S. Lucas, Jessica Orf, Minqing Rong, Maria M. Toteva, Dineli Wickramasinghe, Guifen Xu,