| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10596828 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
Structure-activity relationships (SAR) of analogues of lead compound 1 were investigated and compound 16 was selected for further study in animal models of pain. Compound 16 was shown to be a potent antihyperalgesic agent in both the rat acute complete Freund's adjuvant (CFA) model of inflammatory pain [Iadarola, M. J.; Douglass, J.; Civelli, O.; Naranjo, J. R. rain Res.1988, 455, 205] and the knee joint model of chronic inflammatory pain [Wilson, A. W.; Medhurst, S. J.; Dixon, C. I.; Bontoft, N. C.; Winyard, L. A.; Brackenborough, K. T.; De Alba, J.; Clarke, C. J.; Gunthorpe, M. J.; Hicks, G. A.; Bountra, C.; McQueen, D. S.; Chessell, I. P. Eur. J. Pain2006, 10, 537].
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Authors
Paul J. Beswick, Andy Billinton, Laura J. Chambers, David K. Dean, Elena Fonfria, Robert J. Gleave, Stephen J. Medhurst, Anton D. Michel, Andrew P. Moses, Sadhana Patel, Shilina A. Roman, Sue Roomans, Stefan Senger, Alexander J. Stevens, Daryl S. Walter,