| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10596836 | Bioorganic & Medicinal Chemistry Letters | 2010 | 5 Pages |
Abstract
We report the efficient synthesis and biological evaluation of new benzodioxinoindolocarbazoles heterocycles (BDCZs) designed as potential anticancer agents. Indolic substitution and maleimide variations were performed to design a new library of BDCZs and their cytotoxicity were evaluated on two representative cancer cell lines. Several derivatives have shown a marked cytotoxicity with IC50 values in the nanomolar range. Results are reported in this Letter.
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Authors
Nathalie Ayerbe, Sylvain Routier, Isabelle Gillaizeau, Carmen Maiereanu, Daniel-Henry Caignard, Alain Pierré, Stéphane Léonce, Gérard Coudert,