| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10596848 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
Medicinal chemistry efforts have identified a quinolinone class of potent NPSR antagonists that readily cross the blood-brain barrier. Optimization efforts resulted in the identification of a potent NPSR antagonist which dose-dependently and specifically inhibited 125I-NPS binding in the CNS when administered to rats.
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Authors
Jeffrey Y. Melamed, Amy E. Zartman, Nathan R. Kett, Anthony L. Gotter, Victor N. Uebele, Duane R. Reiss, Cindra L. Condra, Christine Fandozzi, Laura S. Lubbers, Blake A. Rowe, Georgia B. McGaughey, Martin Henault, Rino Stocco, John J. Renger,