| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10596854 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
The synthesis and SAR of tetracyclic MK2 inhibitors is reported. Tetracyclic lactams showed good selectivity profiles and potently inhibited TNFα release from hPBMCs. Tetracyclic ketone 14F was orally bioavailable and inhibited the LPS induced release of TNFα in mice.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Laszlo Revesz, Achim Schlapbach, Reiner Aichholz, Roland Feifel, Stuart Hawtin, Richard Heng, Peter Hiestand, Wolfgang Jahnke, Guido Koch, Markus Kroemer, Henrik Möbitz, Clemens Scheufler, Juraj Velcicky, Christine Huppertz,