| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10596858 | Bioorganic & Medicinal Chemistry Letters | 2005 | 5 Pages |
Abstract
The protein structure guided design of a series of pyrazolo[1,5-a]pyrimidines with high potency for human cyclin-dependent kinase 2 (CDK2) is described. Some examples were shown to inhibit the growth of human colon tumour cells, were equipotent for CDK1 and were selective against GSK-3β and other kinases.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
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Authors
Douglas S. Williamson, Martin J. Parratt, Justin F. Bower, Jonathan D. Moore, Christine M. Richardson, Pawel Dokurno, Andrew D. Cansfield, Geraint L. Francis, Richard J. Hebdon, Rob Howes, Philip S. Jackson, Andrea M. Lockie, James B. Murray,