| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10596861 | Bioorganic & Medicinal Chemistry Letters | 2005 | 5 Pages |
Abstract
The racemic (±) compound is more potent at the α4β2 nicotinic receptor (Ki = 0.39 nM) than any previously reported bridged nicotinoid, establishing an important role of the 6â²-methyl substituent in this pharmacophore model.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
![6â²-Methylpyrido[3,4-b]norhomotropane: synthesis and outstanding potency in relation to the α4β2 nicotinic receptor pharmacophore model](/preview/png/10596861.png "First Page Preview: 6â²-Methylpyrido[3,4-b]norhomotropane: synthesis and outstanding potency in relation to the α4β2 nicotinic receptor pharmacophore model")
Authors
David B. Kanne, Motohiro Tomizawa, Kathleen A. Durkin, John E. Casida,