| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10596862 | Bioorganic & Medicinal Chemistry Letters | 2005 | 5 Pages |
Abstract
A series of C6-carbamate ketolides with C2-fluorination and C9-oximation was synthesized and shown to have in vitro activity that is superior to erythromycin and comparable to telithromycin. In vivo activity was adversely affected by fluorination, possibly as a result of increased serum protein binding.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Xiaodong Xu, Todd Henninger, Darren Abbanat, Karen Bush, Barbara Foleno, Jamese Hilliard, Mark Macielag,