| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10596866 | Bioorganic & Medicinal Chemistry Letters | 2005 | 5 Pages |
Abstract
3-(Imidazo[1,2-a]pyridin-3-yl)-, its aza-analogs, and 3-(pyrazolo[1,5-a]pyridin-3-yl)-4-(2-acyl-(1,2,3,4-tetrahydro[1,4]diazepino[6,7,1-hi]indol-7-yl))maleimides are very potent inhibitors of GSK3 (⩽5 nM) with >160 to >10,000-fold selectivity versus CDK2/4 and PKCβII.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Thomas A. Engler, Sushant Malhotra, Timothy P. Burkholder, James R. Henry, David Mendel, Warren J. Porter, Kelly Furness, Clive Diefenbacher, Angela Marquart, Jon K. Reel, Yihong Li, Joshua Clayton, Brian Cunningham, Johnathan McLean, John C. O'Toole,