| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10596921 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
Abstract
A series of tryptamine-based human β3-adrenergic receptor (AR) agonists were synthesized in an effort to improve oral bioavailability. Cinnamylamine analog 16i exhibited an excellent agonistic profile in vitro and good oral bioavailability in rats.
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Authors
Masaaki Sawa, Kazuhiro Mizuno, Hiroshi Harada, Hirotaka Tateishi, Yukiyo Arai, Shinya Suzuki, Mayumi Oue, Hiroshi Tsujiuchi, Yasuji Furutani, Shiro Kato,