| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10596927 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
Abstract
The C(2) 3,5-dichlorophenyl-, C(4) carboxyl-, C(5) alkyl-substituted oxazole derivatives synthesized in this study exhibit substantial transthyretin fibril formation inhibition activity in vitro and acceptable binding selectivity in human plasma making them appealing drug candidates against neuropathologies associated with transthyretin amyloidogenesis.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Hossein Razavi, Evan T. Powers, Hans E. Purkey, Sara L. Adamski-Werner, Kyle P. Chiang, Maria T.A. Dendle, Jeffery W. Kelly,