Article ID Journal Published Year Pages File Type
10596933 Bioorganic & Medicinal Chemistry Letters 2005 4 Pages PDF
Abstract
The mean molecular weight of synthetic oral drugs has increased substantially over the past 60 years. Fewer than 5% of oral drugs approved or marketed since 1937 have more than 4-H bond donors and only 2% have MW > 500 and >3 H-bond donors.
Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
Preview
The evolution of synthetic oral drug properties
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