| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10596963 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
Abstract
LFA-1 is a member of the β2-integrin family and is expressed on all leukocytes. This paper describes the de novo design, synthesis, and in vitro activity of LFA-1 antagonists based on a bicyclic[5.5]hydantoin scaffold.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
![De novo design, synthesis, and in vitro activity of LFA-1 antagonists based on a bicyclic[5.5]hydantoin scaffold](/preview/png/10596963.png "First Page Preview: De novo design, synthesis, and in vitro activity of LFA-1 antagonists based on a bicyclic[5.5]hydantoin scaffold")
Authors
Dominique Potin, Michele Launay, Eric Nicolai, Maud Fabreguette, Patrice Malabre, François Caussade, Dominique Besse, Stacey Skala, Dawn K. Stetsko, Gordon Todderud, Brett R. Beno, Daniel L. Cheney, Chiehying J. Chang, Steven Sheriff,