Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10598134 | Bioorganic & Medicinal Chemistry Letters | 2005 | 5 Pages |
Abstract
Starting from a PDE IV inhibitor hit derived from high throughput screening of the compound collection, a key pyrrolidine cyanamide pharmacophore was identified. Modifications of the pyrrolidine ring produced enhancements in cathepsin K inhibition. An X-ray co-crystal structure of a cyanamide with cathepsin K confirmed the mode of inhibition.
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Authors
David N. Deaton, Anne M. Hassell, Robert B. McFadyen, Aaron B. Miller, Larry R. Miller, Lisa M. Shewchuk, Francis X. Tavares, Derril H. Willard, Lois L. Wright,