| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10598264 | Bioorganic & Medicinal Chemistry Letters | 2005 | 5 Pages |
Abstract
To develop novel PPARγ agonists, we synthesized several 3-{4-(2-aminoethoxy)phenyl}propanoic acid derivatives designed on the basis of the structures of rosiglitazone and 15d-PGJ2. In this series, compound 9 was found to be as potent as rosiglitazone. A binding mode analysis of 9 using computer calculations is also reported.
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Authors
Shinya Usui, Takayoshi Suzuki, Yoshifumi Hattori, Kazuma Etoh, Hiroki Fujieda, Makoto Nishizuka, Masayoshi Imagawa, Hidehiko Nakagawa, Kohfuku Kohda, Naoki Miyata,