| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10598269 | Bioorganic & Medicinal Chemistry Letters | 2005 | 7 Pages |
Abstract
We have identified and synthesized a series of phenyl-tetrazolyl and 4-thiopyridyl indanones as allosteric potentiators of the metabotropic glutamate receptor 2. Structure activity relationship studies directed toward improving the potency and level of potentiation, as well as PK properties, led to the discovery of 28 (EC50Â =Â 186Â nM), which displayed activity in a rodent model for schizophrenia.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Anthony B. Pinkerton, Rowena V. Cube, John H. Hutchinson, Joyce K. James, Michael F. Gardner, Blake A. Rowe, Hervé Schaffhauser, Dana E. Rodriguez, Una C. Campbell, Lorrie P. Daggett, Jean-Michel Vernier,