| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10598279 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
Abstract
Dipeptide esters of paracetamol were prepared and observed to be quantitatively hydrolyzed to paracetamol and 2,4-diketopiperazines at pH 7.4 and 37 °C. Hydrolysis rates depended on dipeptide structure. These novel compounds do not affect the levels of hepatic glutathione.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Cledir Santos, Maria LuÃsa Mateus, Ana Paula dos Santos, Rui Moreira, Eliandre de Oliveira, Paula Gomes,