| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10598306 | Bioorganic & Medicinal Chemistry Letters | 2005 | 6 Pages |
Abstract
The synthesis and evaluation as tryptase inhibitors of a library of DKP derivatives containing guanidine or amidine functional groups is reported. Among the compounds evaluated, derivatives 6{CG4-CG8} and 6{CG4-CG9} are the most active compounds and have marked selectivity towards tryptase in front of trypsine.
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Authors
Montserrat del Fresno, Dolors Fernández-Forner, Montserrat Miralpeix, Victor Segarra, Hamish Ryder, Miriam Royo, Fernando Albericio,