| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10598323 | Bioorganic & Medicinal Chemistry Letters | 2005 | 5 Pages |
Abstract
4-Arylsulfone derivatives of 1-(1-naphthyl)piperazine represent a novel class of human 5-HT6 serotonin receptor ligands. In particular, compounds such as 1f (1; R = H; Ki = 3.8 nM) and 1g (1; R = NH2; Ki = 0.9 nM) displayed high affinity for this receptor population, and 1f was shown to behave as a 5-HT6 antagonist.
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Authors
Mase Lee, Jagadeesh B. Rangisetty, Manik R. Pullagurla, MaÅgorzata Dukat, Vince Setola, Bryan L. Roth, Richard A. Glennon,