Article ID Journal Published Year Pages File Type
10598334 Bioorganic & Medicinal Chemistry Letters 2005 5 Pages PDF
Abstract
New ethynyl and ethenyl-4-phenylamino-3-quinolinecarbonitrile derivatives were synthesized and tested for Src inhibition. The N-oxide derivative 20b is the first 3-quinolinecarbonitrile to show subnanomolar inhibitory activity in a Src enzyme assay.
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Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
Preview
Further studies on ethenyl and ethynyl-4-phenylamino-3-quinolinecarbonitriles: identification of a subnanomolar Src kinase inhibitor
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