| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10598335 | Bioorganic & Medicinal Chemistry Letters | 2005 | 5 Pages |
Abstract
The chemoattractant receptor-homologous molecule expressed on TH2 cells (CRTH-2), also found on eosinophils and basophils, is a prostaglandin D2 receptor involved in the recruitment of these cell types during an inflammatory response. In this report, we describe the synthesis and optimization of a ramatroban isostere that is a selective and potent antagonist of CRTH-2 which may be useful in the treatment of certain diseases.
Keywords
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Michael J. Robarge, David C. Bom, L. Nathan Tumey, Norbert Varga, Elizabeth Gleason, Daniel Silver, Jianping Song, Steven M. Murphy, George Ekema, Chris Doucette, Doug Hanniford, Marc Palmer, Gary Pawlowski, Joel Danzig, Margaret Loftus, Karen Hunady,