| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10598349 | Bioorganic & Medicinal Chemistry Letters | 2005 | 6 Pages |
Abstract
A series of novel macrocyclic amide-urethanes was designed and synthesized based upon the X-ray crystal structure. Inhibitors containing 14- to 16-membered rings exhibited low nanomolar inhibitory potencies against memapsin 2.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Arun K. Ghosh, Thippeswamy Devasamudram, Lin Hong, Christopher DeZutter, Xiaoming Xu, Vajira Weerasena, Gerald Koelsch, Geoffrey Bilcer, Jordan Tang,