| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10598376 | Bioorganic & Medicinal Chemistry Letters | 2005 | 6 Pages |
Abstract
A series of non-amide-linked 6-substituted-2-naphthamidine urokinase plasminogen activator (uPA) inhibitors are described. These compounds possess excellent binding activities and selectivities with significantly improved pharmacokinetic profiles versus previously described amide-linked inhibitors.
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Authors
Milan Bruncko, William J. McClellan, Michael D. Wendt, Daryl R. Sauer, Andrew Geyer, Christopher R. Dalton, Michele A. Kaminski, Moshe Weitzberg, Jane Gong, Joseph F. Dellaria, Robert Mantei, Xumiao Zhao, Vicki L. Nienaber, Kent Stewart,