Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10598388 | Bioorganic & Medicinal Chemistry Letters | 2005 | 5 Pages |
Abstract
Association between RNA and DNA strands to form RNA-DNA heteroduplex is important in many biological processes. Herein, binding affinities of a 17-mer BIV Tat peptide is compared with TAR DNA duplex, RNA-DNA heteroduplex and RNA duplex. It was observed that binding affinities of Tat peptide is comparable against DNA-RNA heteroduplex and RNA duplex, whereas DNA duplex binding is decidedly poor.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jeffrey B.-H. Tok, Lanrong Bi,