| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10598418 | Bioorganic & Medicinal Chemistry Letters | 2005 | 7 Pages |
Abstract
The present study describe the dominating role of surface tension (ST) on the modeling, monitoring, and estimating pKa for a large series of 43 substituted sulfonamides. Because of direct correlation of ST with parachor (Pc) vis-Ã -vis molecular volume (MV), ST is considered as a steric parameter. Single as well as multi-parametric regressions have indicated that ST has a dominating role in QSAR of the set of sulfonamides used and that excellent results are obtained in multi-parametric regression analysis. The results are discussed critically on the basis of statistics.
Related Topics
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Authors
Mamta Thakur, Abhilash Thakur, Padmakar V. Khadikar, Claudiu T. Supuran,