| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10598421 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
Abstract
2,3-Diphenylpropionic acid derivatives as highly potent VLA-4 antagonists are described. One representative compound, 9cc has inhibited intercellular adhesion by a VCAM-1/VLA-4 interaction with an IC50 of 1.7Â nM, and has good pharmacokinetics and oral bioavailability.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yoichiro Hoshina, Satoru Ikegami, Akihiko Okuyama, Hideto Fukui, Kiyoshi Inoguchi, Tatsuya Maruyama, Kyoko Fujimoto, Yuzuru Matsumura, Akinori Aoyama, Tatsuhiro Harada, Hiroshi Tanaka, Tsutomu Nakamura,