Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10598428 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
Abstract
The synthesis of novel 1β-methylcarbapenems 1a,b having sodium 5-(3- and 5-carboxylic acid)isoxazoloethenyl moieties at C-5 position of pyrrolidine ring and their biological evaluation are described. Both compounds showed potent and well-balanced antibacterial activity as well as high stability to DHP-I. The selected sodium 3-carboxylic acid derivative 1a possessed excellent DHP-I stability and advanced pharmacokinetic parameters in comparison with 2 and meropenem.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Kyung Seok Lee, Yong Koo Kang, Kyung Ho Yoo, Dong Chan Kim, Kye Jung Shin, Young-Sook Paik, Dong Jin Kim,