Article ID Journal Published Year Pages File Type
10598788 Bioorganic & Medicinal Chemistry Letters 2005 4 Pages PDF
Abstract
A series of new triazole-containing ketolides and 2-fluoro-ketolides in which the 5-O-desosamine was replaced by unnatural sugars was synthesized and evaluated against relevant macrolide-sensitive and macrolide-resistant respiratory pathogens. Excellent in vitro antibacterial activities were demonstrated for ketolide analogues having the 6′-OBz-3′-dimethylamino-glucose and 6′-OBz-4′-deoxy-3′-dimethylamino-glucose substituents.
Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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