| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10598873 | Bioorganic & Medicinal Chemistry Letters | 2005 | 6 Pages |
Abstract
The design, synthesis and evaluation of 24 isoindolinones as potential inhibitors of the MDM2-p53 interaction is described. The most potent inhibitor NU8231 (ELISA: IC50 = 5.3 ± 0.9 μM) displays cellular activity in human SJSA cells.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ian R. Hardcastle, Shafiq U. Ahmed, Helen Atkins, A. Hilary Calvert, Nicola J. Curtin, Gillian Farnie, Bernard T. Golding, Roger J. Griffin, Sabrina Guyenne, Claire Hutton, Per Källblad, Stuart J. Kemp, Martin S. Kitching, David R. Newell,