| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10598993 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
Abstract
The synthesis and SAR of a new class of CCR2 antagonists based on the lead compound 1a are described. The optimization of the initial lead delivered nanomolar inhibitors of the MCP-1 induced Ca-flux in human THP-1 cells.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Guy Van Lommen, Julien Doyon, Erwin Coesemans, Staf Boeckx, Marina Cools, Mieke Buntinx, Bart Hermans, Jean VanWauwe Jean VanWauwe,