| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10599051 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
Abstract
Photosensitized one-electron oxidation of 5-methylcytosine in DNA by 2-methyl-1,4-naphthoquinone, attached to 5â²-end of an oligodeoxynucleotide strand, produced 5-formylcytosine and led to selective DNA strand cleavage at the original 5-methylcytosine configuration. This specified photoreaction is useful for positive display of 5-methylcytosine in DNA on a sequencing gel.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Hisatsugu Yamada, Kazuhito Tanabe, Sei-ichi Nishimoto,