| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10599091 | Bioorganic & Medicinal Chemistry Letters | 2005 | 5 Pages |
Abstract
Non-peptidic small molecule SMAC mimetics were designed and synthesized that bind to the BIR3 domain of XIAP using structure-based design. Substituted five-membered heterocycles such as thiazoles and imidazoles were identified that serve as replacements for peptide fragments of the lead.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Cheol-Min Park, Chaohong Sun, Edward T. Olejniczak, Alan E. Wilson, Robert P. Meadows, Stephen F. Betz, Steven W. Elmore, Stephen W. Fesik,