| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10599096 | Bioorganic & Medicinal Chemistry Letters | 2005 | 5 Pages |
Abstract
The synthesis and structure-activity relationships of N-arylalkylpiperidylmethyl ureas as antagonists of the CC chemokine receptor-3 (CCR3) are presented. These compounds displayed potent binding to the receptor as well as functional antagonism of eotaxin-elicited effects on eosinophils.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Douglas G. Batt, Gregory C. Houghton, John Roderick, Joseph B. III, Dean A. Wacker, Patricia K. Welch, Yevgeniya I. Orlovsky, Eric A. Wadman, James M. Trzaskos, Paul Davies, Carl P. Decicco, Percy H. Carter,