| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10599108 | Bioorganic & Medicinal Chemistry Letters | 2005 | 6 Pages |
Abstract
Proof of concept experiments have shown that tissue factor/factor VIIa inhibitors have antithrombotic activity without enhancing bleeding propensity. Starting from lead compounds generated by a biased combinatorial approach, phenylglycine amide tissue factor/factor VIIa inhibitors with low nanomolar affinity and good selectivity against other serine proteases of the coagulation cascade were designed.
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Authors
Katrin Groebke Zbinden, David W. Banner, Jean Ackermann, Allan D'Arcy, Daniel Kirchhofer, Yu-Hua Ji, Thomas B. Tschopp, Sabine Wallbaum, Lutz Weber,