| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10599297 | Bioorganic & Medicinal Chemistry Letters | 2005 | 5 Pages |
Abstract
We describe the identification and SAR of a series of low nanomolar inhibitors of FEN1, an enzyme involved in DNA repair pathways. These inhibitors have been shown to sensitize certain cell lines to DNA damage.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
L. Nathan Tumey, David Bom, Bayard Huck, Elizabeth Gleason, Jianmin Wang, Daniel Silver, Kurt Brunden, Sherry Boozer, Stephen Rundlett, Bruce Sherf, Steven Murphy, Tom Dent, Christina Leventhal, Andrew Bailey, John Harrington, Youssef L. Bennani,