| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10599317 | Bioorganic & Medicinal Chemistry Letters | 2005 | 5 Pages |
Abstract
In order to find novel non-hydroxamate histone deacetylase (HDAC) inhibitors, we synthesized several suberoylanilide hydroxamic acid (SAHA)-based compounds designed on the basis of the catalytic mechanism of HDACs. Among these compounds, mercaptoacetamide 5b was found to be as potent as SAHA. Kinetic enzyme assays and molecular modeling are also reported.
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Authors
Takayoshi Suzuki, Azusa Matsuura, Akiyasu Kouketsu, Hidehiko Nakagawa, Naoki Miyata,