Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10599319 | Bioorganic & Medicinal Chemistry Letters | 2005 | 7 Pages |
Abstract
Some novel oxazolidinone derivatives have been synthesized and tested for antibacterial activity. Compound 13 was found to be active against Gram-positive pathogens whereas compound 14 was less active. Either less active or inactive molecules were obtained, when benzotriazole was replaced with benzimidazole, benzthiazole, or benzoxazole. However, thioacetamide analogue of 13 produced a potent molecule similar to linezolid in vitro.
Related Topics
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Authors
Jagattaran Das, C.V. Laxman Rao, T.V.R.S. Sastry, M. Roshaiah, P. Gowri Sankar, Abdul Khadeer, M. Sitaram Kumar, Arundhuti Mallik, N. Selvakumar, Javed Iqbal, Sanjay Trehan,