| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10599327 | Bioorganic & Medicinal Chemistry Letters | 2005 | 6 Pages |
Abstract
A series of selective PPARγ modulators (SPPARγMs) and their development from hPPARγ active screening leads 1 and 2 is described. SPPARγM 24 displayed robust anti-diabetic activity with an improved therapeutic window in comparison to a PPARγ full agonist in a rodent efficacy model.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
John J. III, Regina M. Black, A. Brian Jones, David E. Moller, Lawrence Colwell, Thomas W. Doebber, Karen L. MacNaul, Joel Berger, Harold B. Wood,