| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10599332 | Bioorganic & Medicinal Chemistry Letters | 2005 | 5 Pages |
Abstract
The development of a series of N1-sulfonyl-3-(1,2,3,6-tetrahydropyridin-4-yl)indole 5-HT6 antagonists is described. Two analogs, 15g and 15y, had 0.4 and 3.0Â nM affinity, and antagonized the production of adenylate cyclase at sub-nanomolar concentrations.
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Authors
Derek C. Cole, John W. Ellingboe, William J. Lennox, Hossein Mazandarani, Deborah L. Smith, Joseph R. Stock, Guoming Zhang, Ping Zhou, Lee E. Schechter,